Abstract Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently. chimeric antigen receptor (CAR) T-cell therapy has been successfully applied in the treatment of B-cell malignancies. underscoring its great potential in antitumor therapy. https://www.bekindtopets.com/great-deal-Psithurisme-Definition-Affiche-great-choice/